医学
胰腺癌
荟萃分析
病态的
危险系数
胰腺切除术
外科
切除术
癌症
内科学
置信区间
作者
Eline S. Zwart,Bengi Su Yilmaz,Asif Halimi,Reea Ahola,Benediktas Kurlinkus,Johanna Laukkarinen,Güralp O. Ceyhan
出处
期刊:Pancreatology
[Elsevier]
日期:2022-09-01
卷期号:22 (6): 803-809
被引量:14
标识
DOI:10.1016/j.pan.2022.05.001
摘要
In pancreatic ductal adenocarcinoma patients with suspected venous infiltration, a R0 resection is most of the time not possible without venous resection (VR). To investigate this special kind of patients, this meta-analysis was conducted to compare mortality, morbidity and long-term survival of pancreatic resections with (VR+) and without venous resection (VR-). A systematic search was performed in Embase, Pubmed and Web of Science. Studies which compared over twenty patients with VR + to VR-for PDAC with ≥1 year follow up were included. Articles including arterial resections were excluded. Statistical analysis was performed with the random effect Mantel-Haenszel test and inversed variance method. Individual patient data was compared with the log-rank test. Following a review of 6403 papers by title and abstract and 166 by full text, a meta-analysis was conducted of 32 studies describing 2216 VR+ and 5380 VR-. There was significantly more post-pancreatectomy hemorrhage (6.5% vs. 5.6%), R1 resections (36.7% vs. 28.6%), N1 resections (70.3% vs. 66.8%) and tumors were significantly larger (34.6 mm vs. 32.8 mm) in patients with VR+. Of all VR + patients, 64.6% had true pathological venous infiltration. The 90-day mortality, individual patient data for overall survival and pooled multivariate hazard ratio for overall survival were similar. VR is a safe and feasible option in patients with pancreatic cancer and suspicion of venous involvement, since VR during pancreatic surgery has comparable overall survival and complication rates.
科研通智能强力驱动
Strongly Powered by AbleSci AI