冲动性
背外侧前额叶皮质
心理学
辅助电机区
斯特罗普效应
前额叶皮质
精神病
形状记忆合金*
神经科学
额叶
精神分裂症(面向对象编程)
运动前皮质
功能磁共振成像
作者
Michael J. Minzenberg,Tyler A. Lesh,Tara A. Niendam,Jong H. Yoon,Yaoan Cheng,Remy N. Rhoades,Cameron S. Carter
出处
期刊:Crisis-the Journal of Crisis Intervention and Suicide Prevention
[Hogrefe Publishing Group]
日期:2015-10-27
卷期号:36 (5): 363-370
被引量:11
标识
DOI:10.1027/0227-5910/a000335
摘要
Abstract. Background: Suicide is prevalent in schizophrenia (SZ), yet the neural system functions that confer suicide risk remain obscure. Circuits operated by the prefrontal cortex (PFC) are altered in SZ, including those that support reactive control, and PFC changes are observed in postmortem studies of heterogeneous suicide victims. Aims: We tested whether history of suicide attempt is associated with altered frontal motor cortex activity during reactive control processes. Method: We evaluated 17 patients with recent onset of DSM-IV-TR-defined SZ using the Columbia Suicide Severity Rating Scale and functional magnetic resonance imaging during Stroop task performance. Group-level regression models relating past suicidal behavior to frontal activation controlled for depression, psychosis, and impulsivity. Results: Past suicidal behavior was associated with relatively higher activation in the left-hemisphere supplementary motor area (SMA), pre-SMA, premotor cortex, and dorsolateral PFC, all ipsilateral t...
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