适体
G-四倍体
计算生物学
核酸
小分子
端粒
RNA剪接
生物
核酸结构
选择性拼接
DNA
核糖核酸
遗传学
基因
外显子
作者
Nilanjan Banerjee,Suman Panda,Subhrangsu Chatterjee
摘要
G-Quadruplex, a unique secondary structure in nucleic acids found throughout human genome, elicited widespread interest in the field of therapeutic research. Being present in key regulatory regions of oncogenes, RNAs and telomere, G-Quadruplex structure regulates transcription, translation, splicing, etc. Changes in its structure and stability leads to differential expression of oncogenes causing cancer. Thus, targeting G-Quadruplex structures with small molecules/other biologics has shown elevated research interest. Covering previous reports, in this review, we try to enlighten the facts on the structural diversity in G-Quadruplex ligands aiming to provide newer insights to design first-in-class drugs for the next-generation cancer treatment.
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