Efficient Synthesis of Medicinally Important Benzylidene-indolin-2-one Derivatives Catalyzed by Biodegradable Amino Sugar “Meglumine”

An efficient synthesis of biologically important benzylidene-indolin-2-one derivatives using meglumine as green catalyst and ethanol:water as reaction media at 78°C has been developed. The effects of reaction conditions such as solvents, temperature, and amount of catalyst were investigated. The present methodology offers many advantages such as simple procedure, less time taking to complete the reaction, high yield of products, and clean reaction profile.