粪便
苯乙酸
丁酸盐
拟杆菌
丙酸盐
食品科学
化学
多酚
乳酸菌
人口
生物化学
生物
微生物学
抗氧化剂
细菌
医学
发酵
环境卫生
遗传学
作者
Isabel Gutiérrez‐Díaz,Tania Fernández-Navarro,Nuria Salazar,Begoña Bartolomé,M. Victoria Moreno‐Arribas,Patricia López,Ana Suárez,Clara G. de los Reyes‐Gavilán,Miguel Gueimonde,Sónia González
标识
DOI:10.1021/acs.jafc.8b04102
摘要
Although most of the health effects attributed to polyphenols may be linked to their phenolic-derived metabolites, the role of the intestinal derived-phenolics in human health is still far from being well understood. We determined the profile of fecal phenolic-derived metabolites, microbiota, biomarkers of oxidative stress and inflammation, and daily intake of bioactive compounds in 71 elderly volunteers. Phenylacetic and phenylpropionic acids were the main phenolic metabolites present in feces. From them, phenylacetic acid was related with a more pro-oxidant and immune stimulated status, and both were negatively associated with fecal propionate, whereas phenylpropionic acid was directly related with the fecal concentration of acetate. Moreover, phenylacetic acid was negatively associated with the Bacteroides group and Clostridium cluster XIVa and positively with Lactobacillus. These results provide a rationale to explore the potential of fecal microbial phenolic-derived metabolites as possible biomarkers of health status in future studies focused on the elderly population.
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