酿酒酵母
合成代谢
生物化学
分解代谢
过氧化物酶体
新陈代谢
代谢工程
代谢途径
酵母
化学
生物
酶
基因
作者
Qian Zhang,Weizhu Zeng,Sha Xu,Jingwen Zhou
标识
DOI:10.1016/j.biortech.2021.125978
摘要
Acetyl-CoA is a kind of important cofactor that is involved in many metabolic pathways. It serves as the precursor for many interesting commercial products, such as terpenes, flavonoids and anthraquinones. However, the insufficient supply of acetyl-CoA limits biosynthesis of its derived compounds in the intracellular. In this review, we outlined metabolic pathways involved in the catabolism and anabolism of acetyl-CoA, as well as some important derived products. We examined several strategies for the enhanced supply of acetyl-CoA, and provided insight into pathways that generate acetyl-CoA to balance metabolism, which can be harnessed to improve the titer, yield and productivities of interesting products in Saccharomyces cerevisiae and other eukaryotic microorganisms. We believe that peroxisomal fatty acid β-oxidation could be an attractive strategy for enhancing the supply of acetyl-CoA.
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