肿瘤坏死因子α
坏死
单因子
免疫学
酵母多糖
生物
医学
B细胞激活因子
细胞因子
体外
病理
白细胞介素
抗体
生物化学
B细胞
作者
E A Carswell,Lloyd J. Old,Robert Kassel,S Green,Nancy C. Fiore,Barbara Williamson
标识
DOI:10.1073/pnas.72.9.3666
摘要
In studying "hemorrhagic necrosis" of tumors produced by endotoxin, it was found that the serum of bacillus Calmette--Guerin (BCG)-infected mice treated with endotoxin contains a substance (tumor necrosis factor; TNF) which mimics the tumor necrotic action of endotoxin itself. TNF-positive serum is as effective as endotoxin itself in causing necrosis of the sarcoma Meth A and other transplanted tumors. A variety of tests indicate that TNF is not residual endotoxin, but a factor released from host cells, probably macrophages, by endotoxin. Corynebacteria and Zymosan, which like BCG induce hyperplasia of the reticulo-endothelial system, can substitute for BCG in priming mice for release of TNF by endotoxin. TNF is toxic in vitro for two neoplastic cell lines; it is not toxic for mouse embryo cultures. We propose that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
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