纳米颗粒
冷冻干燥
纳米技术
过程(计算)
胶体
粒径
粒子(生态学)
材料科学
工艺工程
化学
生化工程
化学工程
计算机科学
色谱法
工程类
海洋学
地质学
操作系统
作者
Wassim Abdelwahed,Ghania Degobert,Serge Stainmesse,Hatem Fessi
标识
DOI:10.1016/j.addr.2006.09.017
摘要
Freeze-drying has been considered as a good technique to improve the long-term stability of colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanoparticles. This article reviews the state of the art of freeze-drying nanoparticles. It discusses the most important parameters that influence the success of freeze-drying of these fragile systems, and provides an overview of nanoparticles freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability.
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