抗药性
背景(考古学)
人类免疫缺陷病毒(HIV)
药品
生物
病毒学
慢病毒
克莱德
遗传多样性
抗性(生态学)
遗传学
病毒性疾病
免疫学
医学
人口
基因
系统发育学
药理学
环境卫生
古生物学
生态学
出处
期刊:AIDS
[Ovid Technologies (Wolters Kluwer)]
日期:2004-06-01
卷期号:18 (Supplement 3): S63-S68
被引量:102
标识
DOI:10.1097/00002030-200406003-00012
摘要
Genetic diversity is a hallmark of HIV-1 infection with regard to the expansion of distinct viral subtypes (clades A, B, C, D, E, F, G, K, and O) in different geographical regions. Here, we discuss the issues of HIV-1 sensitivity to antiretroviral drugs and drug resistance in the context of HIV-1 subtype diversity. Virtually all available evidence suggests that all subtypes of HIV display similar sensitivity to antiviral drugs, but viruses from some subtypes or geographical regions may occasionally have a greater propensity to develop resistance against certain drugs than other viral variants. In some situations, the types of mutations associated with resistance may vary, as a result of subtle differences among subtypes with regard to the genetic code. This consideration notwithstanding, drug resistance is unlikely to become a more serious issue in developing than developed countries, and there is an urgency to make anti-HIV drugs available to all who are in need.
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