肿瘤微环境
STAT蛋白
斯达
免疫系统
生物
癌症研究
癌症干细胞
串扰
癌症免疫疗法
干细胞
细胞生物学
免疫学
信号转导
免疫疗法
车站3
物理
光学
作者
Mengxuan Zhu,Suyao Li,Xin Cao,Khalid Rashid,Tianshu Liu
标识
DOI:10.1016/j.semcancer.2022.11.011
摘要
Signal transducer and activator of transcription (STAT) proteins compose a family of transcription factors critical for cancer stem cells (CSCs), and they are involved in maintaining stemness properties, enhancing cell proliferation, and promoting metastasis. Recent studies suggest that STAT proteins engage in reciprocal communication between CSCs and infiltrate immune cell populations in the tumor microenvironment (TME). Emerging evidence has substantiated the influence of immune cells, including macrophages, myeloid-derived suppressor cells, and T cells, on CSC survival through the regulation of STAT signaling. Conversely, dysregulation of STATs in CSCs or immune cells contributes to the establishment of an immunosuppressive TME. Thus, STAT proteins are promising therapeutic targets for cancer treatment, especially when used in combination with immunotherapy. From this perspective, we discuss the complex roles of STATs in CSCs and highlight their functions in the crosstalk between CSCs and the immune microenvironment. Finally, cutting-edge clinical trial progress with STAT signaling inhibitors is summarized.
科研通智能强力驱动
Strongly Powered by AbleSci AI