真皮
表皮(动物学)
皮肤修复
皮肤老化
人体皮肤
皮肤癌
病理
势垒函数
伤口愈合
皮肤当量
皮肤病科
解剖
医学
细胞生物学
癌症
生物
角质形成细胞
免疫学
内科学
体外
遗传学
生物化学
标识
DOI:10.1016/j.jdermsci.2023.08.006
摘要
Human skin is the most widespread and abundant type of tissue in the human body. With the passage of time, most of our organs, including a substantial part of the skin, tend to undergo a gradual thinning or decrease in size. As we age, there is a gradual and progressive reduction in the thickness of both the epidermis and dermis layers of our skin. This is primarily attributed to the decline of epidermal stem cells and the loss of dermal collagen, which is the most abundant protein in the human body. Age-related alterations of the epidermis and dermis impair skin structure/function and create a tissue microenvironment that promotes age-related skin diseases, such as impaired skin barrier, delayed wound healing, and skin cancer development. This review will examine the current body of literature pertaining to our knowledge of skin epidermal and dermal aging.
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