生物
Rust(编程语言)
吸器
代谢物
生物化学
小麦叶锈病
代谢组学
基因
转录组
白芍
寄主(生物学)
植物
基因表达
遗传学
毒力
计算机科学
程序设计语言
医学
生物信息学
替代医学
病理
作者
Yuping Lu,Ian W. Burton,Paula Ashe,Antony D. St‐Jacques,Nandhakishore Rajagopalan,Fanny Monteil‐Rivera,Michèle C. Loewen
出处
期刊:Gene
[Elsevier]
日期:2024-01-01
卷期号:893: 147927-147927
标识
DOI:10.1016/j.gene.2023.147927
摘要
Recent semi-targeted metabolomics studies have highlighted a number of metabolites in wheat that associate with leaf rust resistance genes and/or rust infection. Here, we report the structural characterization of a novel glycosylated and partially saturated apocarotenoid, reminiscent of a reduced form of mycorradicin, (6E,8E,10E)-4,9-dimethyl-12-oxo-12-((3,4,5-trihydroxy-6-(2-hydroxyethoxy)tetrahydro-2H-pyran-2-yl)methoxy)-3-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dodeca-6,8,10-trienoic acid, isolated from Triticum aestivum L. (Poaceae) variety 'Thatcher' (Tc) flag leaves. While its accumulation was not associated with any of Lr34, Lr67 or Lr22a resistance genes, infection of Tc with leaf rust was found to deplete it, consistent with the idea of this metabolite being a glycosylated-storage form of an apocarotenoid of possible relevance to plant defense. A comparative analysis of wheat transcriptomic changes shows modulation of terpenoid, carotenoid, UDP-glycosyltransferase and glycosylase -related gene expression profiles, consistent with anticipated biosynthesis and degradation mechanisms. However, details of the exact nature of the relevant pathways remain to be validated in the future. Together these findings highlight another example of the breadth of unique metabolites underlying plant host-fungal pathogen interactions.
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