内科学
脂解
脂肪甘油三酯脂肪酶
内分泌学
射血分数
心力衰竭
舒张期
酮体
甘油三酯
医学
过剩4
心脏病学
化学
新陈代谢
胰岛素
胰岛素抵抗
脂肪组织
胆固醇
血压
作者
Santosh K. Maurya,Andrew N. Carley,Chandan Kumar Maurya,E. Douglas Lewandowski
标识
DOI:10.1016/j.jacbts.2022.10.009
摘要
Western diet (WD) impairs glucose tolerance and cardiac lipid dynamics, preceding heart failure with reduced ejection fraction (HFrEF) in mice. Unlike diabetic db/db mice with high cardiac triglyceride (TG) and rapid TG turnover, WD mice had high TG but slowed turnover, reducing lipolytic PPAR⍺ activation. WD deranged cardiac TG dynamics by imbalancing synthesis and lipolysis, with low cardiac TG lipase (ATGL), low ATGL co-activator, and high ATGL inhibitory peptide. By 24 weeks of WD, hearts shifted from diastolic dysfunction to diastolic dysfunction with HFrEF with decreases in GLUT4 and exogenous glucose oxidation and elevated β-hydroxybutyrate dehydrogenase 1 without increasing ketone oxidation.
科研通智能强力驱动
Strongly Powered by AbleSci AI