羟乙基淀粉
复苏
医学
重症监护医学
新鲜冰冻血浆
凝血病
休克(循环)
液体置换
血管内容积状态
弥漫性血管内凝血
损伤控制手术
失血性休克
麻醉
外科
内科学
血流动力学
血小板
作者
Andreas Markl-Le-Lev ́e,Ingrid Haller,Mirjam Bachler
标识
DOI:10.1097/aco.0000000000001481
摘要
Purpose of review Fluid management in hemorrhagic shock is a controversial topic, and there are evolving clinical guidelines and evidence-based practice. This review aims to highlight the physiological aspects in the light of current evidence on which volume replacement solution to use. Recent findings Current evidence and international guidelines are shifting from a liberal to a restrictive fluid resuscitation strategy, emphasizing the potential risks associated with aggressive fluid therapy. The ‘lethal triad of trauma’ (hypoperfusion, acidosis, and coagulopathy) plays a crucial role in the pathophysiology of hemorrhagic shock. While crystalloids are less effective at restoring intravascular volume, colloids (especially hydroxyethyl starch) have raised concerns about potential adverse effects on renal function and coagulation. Albumin remains controversial, as studies showing no clear benefit and an increased mortality in traumatic brain injury patients. Fresh frozen plasma, may be useful in massive transfusion situations but is not recommended for volume resuscitation. Summary The management of fluid resuscitation evolves, with a trend toward more restrictive strategies. Crystalloids, although less effective for severe volume depletion, remain a cornerstone of initial resuscitation. Among the colloids, gelatin-based solutions and albumin can be used when crystalloids are inadequate, while hydroxyethyl starch is no longer recommended.
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