Straightforward Synthesis of Trifluoromethylated Arenes via Copper‐Mediated Trifluoromethylation of Diaryliodonium Salts with Fluoroform

Abstract A mild and efficient copper‐mediated trifluoromethylation of diaryliodonium salts with readily available fluoroform has been developed. The reaction exhibits excellent functional group tolerance, affording trifluoromethylated arenes in good yields. This approach provides a straightforward incorporation of CF 3 group into complex molecules for drug discovery.