A model for identification of potential phase-separated proteins based on protein sequence, structure and cellular distribution

细胞器 计算生物学 鉴定(生物学) 高分子 化学 肽序列 生物 细胞生物学 生物物理学 生物化学 基因 植物
作者
Jiyan Wang,Hongkai Chang,Xiaojing Quan,Xintong Dai,Wang Yan,Chenxi Wang,Shuai Zhang,Changliang Shan
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:243: 125196-125196 被引量:1
标识
DOI:10.1016/j.ijbiomac.2023.125196
摘要

The cells are like a highly industrialized and urbanized city, filled with numerous biological macromolecules and metabolites, forming a crowded environment. While, the cells have compartmentalized organelles to complete different biological processes efficiently and orderly. However, membraneless organelles are more dynamic and adaptable for transient events including signal transduction and molecular interactions. Liquid-liquid phase separation (LLPS) is a mechanism that is widespread in which macromolecules form condensates without membranes to exert biological functions in crowded environments. Due to the lack of deep understanding of phase-separated proteins, platforms exploring phase-separated proteins by high-throughput methods is lacking. Bioinformatics has its unique properties and has proven to be a great impetus in multiple fields. Here, We integrated the amino acid sequence, protein structure, and cellular localization, then developed a workflow for screening phase-separated proteins and identified a novel cell cycle-related phase separation protein, serine/arginine-rich splicing factor 2 (SRSF2). In conclusion, we developed a workflow as a useful resource for predicting phase-separated proteins based on multi-prediction tool, which has an important contribution to the further identification of phase-separated proteins and the development strategies for treating disease.
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