肾透明细胞癌
癌症研究
糖酵解
下调和上调
瓦博格效应
细胞生长
体内
生物
肿瘤进展
细胞
肾细胞癌
癌症
医学
基因
内科学
内分泌学
新陈代谢
生物化学
遗传学
作者
Zonglong Wu,Liyuan Ge,Yimeng Song,Shaohui Deng,Peichen Duan,Tan Du,Yaqian Wu,Zhanyi Zhang,Xiaofei Huang,Lulin Ma,Shudong Zhang
标识
DOI:10.1007/s12672-023-00696-1
摘要
Abstract Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urogenital tract. Given that ccRCC is often resistant to radiotherapy and traditional chemotherapy, the clinical treatment of patients with ccRCC remains a challenge. The present study found that ATAD2 was significantly upregulated in ccRCC tissues. In vitro and in vivo experiments showed that the inhibition of ATAD2 expression mitigated the aggressive phenotype of ccRCC. ATAD2 was also associated with glycolysis in ccRCC. Interestingly, we found that ATAD2 could physically interact with c-Myc and promote the expression of its downstream target gene, thereby enhancing the Warburg effect of ccRCC. Overall, our study emphasizes the role of ATAD2 in ccRCC. The targeted expression or functional regulation of ATAD2 could be a promising method to reduce the proliferation and progression of ccRCC.
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