医学
加替沙星
菌群(微生物学)
随机对照试验
眼科
前瞻性队列研究
外科
抗生素
遗传学
环丙沙星
细菌
微生物学
生物
作者
Jason M. Moss,Steven R. Sanislo,Christopher N. Ta
出处
期刊:Ophthalmology
[Elsevier]
日期:2009-08-01
卷期号:116 (8): 1498-1501
被引量:104
标识
DOI:10.1016/j.ophtha.2009.02.024
摘要
Purpose
We sought to assess the efficacy of 3-day topical gatifloxacin use in combination with povidone-iodine (PVI) versus PVI alone in eliminating conjunctival bacterial flora in patients scheduled to undergo intravitreal (IVT) injection. Design
Prospective, randomized single-blind clinical trial. Participants
We included 129 patients scheduled to undergo 273 IVT injections at California Vitreoretinal Center at Stanford University. Methods
Study patients were randomized to self-administration of gatifloxacin drops for 3 days before injection, or no pretreatment antibiotics. Cultures were collected from the bulbar conjunctiva at the injection site and at the corresponding location in the fellow eye before PVI preparation. After topical PVI treatment and immediately before injection, a third culture was obtained at the injection site. Additionally, the injection needle was also cultured after the procedure. Main Outcome Measures
Incidence of positive bacterial samples collected from injection site conjunctiva and injection needles. Results
Three-day gatifloxacin use resulted in a significantly lower rate of SeptiChek (Becton Dickinson, Franklin Lakes, NJ) positive cultures compared with untreated controls (21% vs 48% respectively, P = 0.005). After topical PVI, the rate of positive bacterial cultures in gatifloxacin-treated and control eyes were similar (8% and 4%, respectively; P = 0.324). Conclusions
Although 3-day topical gatifloxacin use is effective in reducing the frequency of conjunctival bacterial growth relative to untreated eyes, antibiotic use confers no additional benefit in combination with PVI than eyes receiving PVI alone. This supports that topical PVI is an effective preinjection monotherapy for infection prophylaxis in the setting of IVT injections. Financial Disclosure(s)
The authors have no proprietary or commercial interest in any materials discussed in this article.
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