医学
奥拉帕尼
贝伐单抗
内科学
维持疗法
BRCA突变
肿瘤科
卵巢癌
化疗
癌症
生物
遗传学
聚合酶
基因
聚ADP核糖聚合酶
作者
Isabelle Ray‐Coquard,Patricia Pautier,Sandro Pignata,David Pérol,Antonio González-Martı́n,Regina Berger,Keiichi Fujiwara,Ignace Vergote,Nicoletta Colombo,Johanna Mäenpää,Frédèric Selle,Jalid Sehouli,Domenica Lorusso,Eva Maria Guerra Alía,Alexander Reinthaller,Shoji Nagao,Claudia Lefeuvre‐Plesse,Ulrich Canzler,Giovanni Scambia,Alain Lortholary
标识
DOI：10.1056/nejmoa1911361
摘要
Olaparib has shown significant clinical benefit as maintenance therapy in women with newly diagnosed advanced ovarian cancer with a BRCA mutation. The effect of combining maintenance olaparib and bevacizumab in patients regardless of BRCA mutation status is unknown.
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