光动力疗法
光敏剂
细胞毒性
转移
表皮生长因子受体
血管生成
结合
化学
活性氧
体内
药理学
医学
癌症研究
癌症
体外
受体
光化学
内科学
生物化学
生物
有机化学
数学分析
数学
生物技术
作者
Ming Xiao,Jiangli Fan,Miao Li,Feng Xu,Xueze Zhao,Dongmei Xi,He Ma,Yueqing Li,Jianjun Du,Wen Sun,Xiaojun Peng
出处
期刊:Biomaterials
[Elsevier]
日期:2020-07-23
卷期号:257: 120262-120262
被引量:29
标识
DOI:10.1016/j.biomaterials.2020.120262
摘要
Photodynamic therapy (PDT) has been successfully demonstrated for anticancer treatment in vivo. However, tumor metastasis during PDT are still inevitable due to the activation of the epidermal growth factor receptor (EGFR). The current work describes the synthesis of a photosensitizer (PS)-EGFR inhibitor conjugate for PDT with simultaneous tumor metastasis inhibition. The conjugate efficiently internalized into cancer cells and generated reactive oxygen species (ROS) under light, indicating strong cytotoxicity even in hypoxic tumor environment. The presence of an EGFR inhibitor significantly inhibited cell migration and invasion. Accordingly, photoactivation of the conjugate resulted in efficient tumor growth inhibition in a 4T1 tumor-bearing mouse model and suppressed angiogenesis and tumor metastasis during PDT. Therefore, combined PDT and EGFR inhibition strategy provides a new platform for future anticancer treatment with high safety.
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