视网膜
Cone(正式语言)
生长锥
谷氨酸受体
突触
细胞生物学
神经科学
突触小泡
生物
兴奋性氨基酸转运体
背
生物物理学
解剖
小泡
生物化学
轴突
膜
受体
计算机科学
算法
作者
Heinz Wässle,Hanna Regus‐Leidig,Silke Haverkamp
摘要
Abstract Cone photoreceptors have a continuous release of glutamate that is modulated by light. Vesicular glutamate transporters (vGluT) play an essential role for sustaining this release by loading synaptic vesicles in the cone synapse, the so‐called cone pedicle. In the present study mouse retinas were immunostained for vGluT1 and vGluT2. vGluT1 was localized to all cone pedicles and rod spherules, whereas vGluT2 was found in only 10% of the cone pedicles. The vGluT2‐expressing cones were characterized in more detail. They are distributed in a regular array, suggesting they are a distinct type. Their proportion does not differ between dorsal (L‐cone‐dominated) and ventral (S‐cone‐dominated) retina, and they are not the genuine blue cones of the mouse retina. During development, vGluT1 and vGluT2 expression in cones starts at around P0 and right from the beginning vGluT2 is only expressed in a subset of cones. Bipolar cells contact the vGluT2‐expressing cones and other cones nonselectively. The possible functional role of vGluT2 expression in a small fraction of cones is discussed. J. Comp. Neurol. 495:544–555, 2006. © 2006 Wiley‐Liss, Inc.
科研通智能强力驱动
Strongly Powered by AbleSci AI