基质金属蛋白酶
淋巴结
淋巴
病理
癌症
转移
医学
肿瘤进展
癌症研究
癌细胞
免疫组织化学
内科学
作者
Daniel Cordeiro Gurgel,José Telmo Valença,Conceição Aparecida Dornelas,Renato Braga Vieira,João Tarcisio Alves Maia-Filho,Roberto César Pereira Lima‐Júnior,Ronaldo A. Ribeiro,Paulo Roberto Carvalho Almeida
出处
期刊:Pathology & Oncology Research
[Frontiers Media SA]
日期:2014-05-06
卷期号:21 (1): 73-81
被引量:10
标识
DOI:10.1007/s12253-014-9790-x
摘要
Metalloproteinase-2 (MMP-2) and -14 (MMP-14) and the tissue inhibitor of metalloproteinases type 2 (TIMP-2) participate in epithelial-mesenchymal transition and tumor progression in many cancers. However, the correlation between these enzymes in gastric cancer and the metastatic potential to their respective lymph node needs to be determined. Here, we evaluated the expression of these enzymes in gastric carcinoma and lymph node metastases and their possible involvement in tumor progression. Histological samples from 83 patients with gastric cancer and their respective lymph nodes were used. MMP-2, MMP-14 and TIMP-2 immunoexpression was scored. TIMP-2 expression in tumor-associated macrophages occurred more frequently than in normal mucosa (P = 0.0128). Female tumor samples presented higher MMP-2 expression (P = 0.0248), while TIMP-2 occurred mainly in patients over 50 years old (P = 0.0034). MMP-2 was higher expressed in primary tumor macrophages than in neoplastic cells (P = 0.0118), and was also seen in macrophages from metastatic-affected lymph nodes of intestinal and diffuse histotypes (P = 0.0006). MMP-2, MMP-14 and TIMP-2 expression in mononuclear cells might be correlated with progression of gastric cancer. MMP-14 production by macrophages appears to be more involved in diffuse gastric cancer progression.
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