纳米囊
材料科学
控制释放
生长因子
再生医学
纳米技术
体内
纳米颗粒
生物医学工程
化学
医学
细胞生物学
干细胞
生物
生物技术
受体
生物化学
作者
Haijun Tian,Juanjuan Du,Jing Wen,Yang Liu,Scott R. Montgomery,Trevor P. Scott,Bayan Aghdasi,Chengjie Xiong,Akinobu Suzuki,Tetsuo Hayashi,Monchai Ruangchainikom,Kevin Phan,Gil Weintraub,Raed Alobaidaan,Samuel S. Murray,Michael D. Daubs,Xianjin Yang,Xiaochen Yuan,Jeffrey C. Wang,Yunfeng Lu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2016-07-19
卷期号:10 (8): 7362-7369
被引量:35
标识
DOI:10.1021/acsnano.5b07950
摘要
Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules.
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