Pediatric-onset aspirin-exacerbated respiratory disease: Clinical characteristics, prevalence, and response to dupilumab

Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and respiratory reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase-1. The syndrome occurs in about 7% of adults with asthma and 25-30% of adults with asthma and CRSwNP.1 AERD is primarily a disease of adult-onset and has a female predominance, with about a 2:1 female to male ratio of disease incidence.2 The prevalence of AERD in the pediatric population is not well defined, with only case reports or small series studies available.