生物
转录组
计算生物学
拟南芥
核糖核酸
N6-甲基腺苷
拟南芥
遗传学
基因
基因表达
甲基化
甲基转移酶
突变体
作者
Lisha Shen,Zhe Liang,Chui Eng Wong,Hao Yu
标识
DOI:10.1016/j.tplants.2019.01.005
摘要
Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret RNA modifications, respectively, are fundamental to understanding the epitranscriptome. Recent technologies have enabled the transcriptome-wide profiling of several mRNA modifications in Arabidopsis thaliana, providing key insights into regulating these modifications and their effects on plant development. Here we review technological innovations and recent progress in epitranscriptomics, with specific focus on N6-methyladenosine (m6A), 5-methylcytosine (m5C), uridylation, and their roles in multiple aspects of plant development.
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