材料科学
透明质酸
表面改性
粘附
涂层
生物医学工程
细胞毒性
复合数
细胞粘附
血小板粘附
纳米技术
化学工程
复合材料
体外
化学
工程类
生物
医学
生物化学
遗传学
作者
Peng Xue,Qian Li,Yuan Li,Lihong Sun,Lei Zhang,Zhigang Xu,Yuejun Kang
标识
DOI:10.1021/acsami.7b10260
摘要
Poly(dimethylsiloxane) (PDMS) has been widely utilized in micro-electromechanical systems (MEMS) and implantable devices. To improve the hemocompatibility of a PDMS-based implant, a facile technique was developed by modifying PDMS with a hyaluronic acid (HA) and polydopamine (PDA) composite (HA/PDA). Under appropriate ratio of HA to PDA, platelet adhesion and activation were considerably reduced on modified PDMS substrates, indicating an enhanced hemocompatibility compared to native PDMS or those coated with HA or PDA solely. HA/PDA coating also posed minimal cytotoxicity on the adhesion and proliferation of endothelial cells (HUVECs). The anti-inflammation effect of the modified PDMS surface was characterized based on the expression of critical cytokines in adherent macrophages. This study revealed that the hemocompatibility, cytotoxicity, and anti-inflammation properties could be tailored conveniently by adjusting the ratio of HA and PDA composite on the modified PDMS surface, which has an exceptional potential as the core or packaging material for constructing implantable devices in biomedical applications.
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