脑深部刺激
癫痫
刺激
耐火材料(行星科学)
医学
神经科学
丘脑
心理学
帕金森病
内科学
材料科学
疾病
复合材料
作者
Chuanliang Xu,Lei Qi,Xueyuan Wang,Frédéric Schaper,Di Wu,Tao Yu,Xiaoming Yan,Guangyuan Jin,Qiao Wang,Xiaopeng Wang,Xinqi Huang,Yuke Wang,Yuanhong Chen,Jinghui Liu,Yuping Wang,Joachim K. Krauss,Robert S. Fisher,Liqiang Ren
标识
DOI:10.1016/j.brs.2023.08.020
摘要
BackgroundDeep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) is an effective treatment for refractory epilepsy; however, seizure outcome varies among individuals. Identifying a reliable noninvasive biomarker to predict good responders would be helpful.ObjectivesTo test whether the functional connectivity between the ANT-DBS sites and the seizure foci correlates with effective seizure control in refractory epilepsy.MethodsWe performed a proof-of-concept pilot study of patients with focal refractory epilepsy receiving ANT-DBS. Using normative human connectome data derived from 1000 healthy participants, we investigated whether intrinsic functional connectivity between the seizure foci and the DBS site was associated with seizure outcome. We repeated this analysis controlling for the extent of seizure foci, distance between the seizure foci and DBS site, and using functional connectivity of the ANT instead of the DBS site to test the contribution of variance in DBS sites.ResultsEighteen patients with two or more seizure foci were included. Greater functional connectivity between the seizure foci and the DBS site correlated with more favorable outcome. The degree of functional connectivity accounted for significant variance in clinical outcomes (DBS site: |r| = 0.773, p < 0.001 vs ANT-atlas: |r| = 0.715, p = 0.001), which remained significant when controlling for the extent of the seizure foci (|r| = 0.773, p < 0.001) and the distance between the seizure foci and DBS site (|r| = 0.777, p < 0.001). Significant correlations were independent of variance in the DBS sites (|r| = 0.148, p = 0.57).ConclusionThese findings suggest that functional connectomic profile is a potential reliable non-invasive biomarker to predict ANT-DBS outcomes. Accordingly, the identification of ANT responders could decrease the surgical risk for patients who may not benefit and optimize the cost-effective allocation of health care resources.
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