抗菌剂
单线态氧
白色念珠菌
活性氧
碳纤维
化学
微生物学
细胞毒性
体外
金黄色葡萄球菌
量子点
纳米技术
材料科学
氧气
生物
生物化学
细菌
有机化学
遗传学
复合数
复合材料
作者
R.L. Ferreira,Walter Muniz,Louise E. A. Souza,Hector Mauricio Casanova Navarro,Lucas R. de Mello,Valmor Roberto Mastelaro,Tasso O. Sales,Cintya D’ Angeles do Espírito Santo Barbosa,Adriana S. Ribeiro,Emerson Rodrigo da Silva,Melissa Fontes Landell,I. N. de Oliveira
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2023-10-04
卷期号:6 (10): 4345-4357
被引量:4
标识
DOI:10.1021/acsabm.3c00541
摘要
The emergence of drug-resistant pathogenic microorganisms has become a public health concern, with demand for strategies to suppress their proliferation in healthcare facilities. The present study investigates the physicochemical and antimicrobial properties of carbon dots (CD-MR) derived from the methyl red azo dye. The morphological and structural analyses reveal that such carbon dots present a significant fraction of graphitic nitrogen in their structures, providing a wide emission range. Based on their low cytotoxicity against mammalian cells and tunable photoluminescence, these carbon dots are applied to bioimaging in vitro living cells. The possibility of using CD-MR to generate reactive oxygen species (ROS) is also analyzed, and a high singlet oxygen quantum efficiency is verified. Moreover, the antimicrobial activity of CD-MR is analyzed against pathogenic microorganisms Staphylococcus aureus, Candida albicans, and Cryptococcus neoformans. Kirby-Bauer susceptibility tests show that carbon dots synthesized from methyl red possess antimicrobial activity upon photoexcitation at 532 nm. The growth inhibition of C. neoformans from CD-MR photosensitization is investigated. Our results show that N-doped carbon dots synthesized from methyl red efficiently generate ROS and possess a strong antimicrobial activity against healthcare-relevant pathogens.
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