PLGA (Poly lactic-co-glycolic acid) and Soybean Phosphatidylcholine loaded Vildagliptin Lipid Polysaccharide Hybrid Nanoparticles: Development and Assessment for Oral Delivery Operations

This study investigates the use of lipid polysaccharide hybrid nanoparticles (LPHNPs) as a drug delivery vehicle for Vildagliptin. The researchers used a nanoprecipitation strategy with PLGA and soybean phosphatidylcholine to create stacked LPHNPs. The study discovered that the nanosized and round LPHNPs had a similar size distribution and significantly improved drug absorption and dissolution in the crossbreed network. The content of polymer led to a rise in the size of the nanoparticles, while the content of lipid and polymer enhanced the efficacy of drug entrapment. The in vitro drug release ranged from 72-94%, and the delivery components followed the Korsmeyer-Peppas model and Fickian diffusion. The study suggests that PLGA and soybean phosphatidylcholine-based framework LPHNPs could be promising for improving Vildagliptin dissolution and increasing its profile accessibility.