Abstract Objective This article aims to describe a systematic method for tooth color reproduction with ceramics restorations employing artificial intelligence (AI) software named Matisse. It provides a comprehensive analysis of the entire process, beginning with shade‐taking and extending to ceramic application in a complex clinical case in the anterior region—specifically, a single central restoration supported by an implant. Clinical Considerations The clinical case presented highlights the potential of Matisse software for generating ceramic (inSync‐Jensen Dental, USA) and staining (Miyo‐Jensen Dental, USA) recipes over a zirconia abutment (Katana‐Noritake Dental, Japan). This approach achieves an optimal single central restoration utilizing CAD‐CAM and layering techniques. Conclusions The systematic method employing the Matisse software achieved accurate color reproduction for a single central restoration supported by an implant. This result was achieved by the dental ceramist within the first attempt and without seeing the patient in the entire process. Clinical Significance The Matisse AI‐assisted protocol offers a systematic and scientifically grounded method for color reproduction in dentistry for indirect restorations.