化学
肽
DNA连接酶
组合化学
立体化学
药物化学
有机化学
生物化学
酶
作者
Marcel Schmidt,Ana Toplak,Peter J. L. M. Quaedflieg,Hans Ippel,Gaston J. J. Richelle,Tilman M. Hackeng,Jan H. van Maarseveen,Timo Nuijens
标识
DOI:10.1002/adsc.201700590
摘要
The inside cover picture, provided by Nuijens and co-workers, illustrates the power and versatility of the peptide ligase omniligase-1. This ligase provides a promising green and clean alternative to chemical approaches used for peptide cyclization, peptide fragment condensation and protein labelling. The ligations are traceless, proceed with very high catalytic efficiency and result in high product yields. Details on omniligase-mediated peptide cyclization can be found in the communication on pages 2050–2055 (M. Schmidt, A. Toplak, P. J. L. M. Quaedflieg, H. Ippel, G. J. J. Richelle, T. M. Hackeng, J. H. van Maarseveen, T. Nuijens, Adv. Synth. Catal. 2017, 359, 2050–2055; DOI: 10.1002/adsc.201700314).
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