自愈水凝胶
超分子化学
材料科学
生物材料
纳米技术
组织工程
聚苯胺
肽
自愈
聚合
生物医学工程
聚合物
高分子化学
化学
分子
生物化学
有机化学
医学
替代医学
病理
复合材料
作者
Priyadarshi Chakraborty,Hadas Oved,Darya Bychenko,Yifei Yao,Yiming Tang,Shai Zilberzwige‐Tal,Guanghong Wei,Tal Dvir,Ehud Gazit
标识
DOI:10.1002/adma.202008715
摘要
Owing to their dynamic nature and ordered architecture, supramolecular materials strikingly resemble organic components of living systems. Although short-peptide self-assembled nanostructured hydrogels are regarded as intriguing supramolecular materials for biotechnology, their application is often limited due to their low stability and considerable challenge of combining other desirable properties. Herein, a di-Fmoc-based hydrogelator containing the cell-adhesive Arg-Gly-Asp (RGD) fragment that forms a mechanically stable, self-healing hydrogel is designed. Molecular dynamics simulation reveals the presence of RGD segments on the surface of the hydrogel fibers, highlighting their cell adherence capacity. Aiming to impart conductivity, the 3D network of the hydrogel is further nanoengineered by incorporating polyaniline (PAni). The composite hydrogels demonstrate semiconductivity, excellent antibacterial activity, and DNA binding capacity. Cardiac cells grown on the surface of the composite hydrogels form functional synchronized monolayers. Taken together, the combination of these attributes in a single hydrogel suggests it as an exceptional candidate for functional supramolecular biomaterial designed for electrogenic tissue engineering.
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