黄曲霉毒素
毒素
遗传毒性
维生素
黄曲霉
视黄醇
精子
真菌毒素
生物
断奶
毒性
口服
碎屑成因
药理学
毒理
男科
内分泌学
内科学
食品科学
医学
生物化学
植物
出处
期刊:PubMed
日期:1994-01-01
卷期号:79 (317): 85-95
被引量:16
摘要
Young weaning Swiss albino mice were orally administered crude aflatoxin B1 in a dose mimicking human exposure condition, i.e. at 0.05 micrograms/kg body weight/day for 14 weeks. Vitamin A (retinol) was orally administered along with the toxin in double (132 IU/kg body wt/day) the human equivalent therapeutic dose. The results suggested that vitamin A minimised the frequency of toxin-induced clastogeny in both mitotic and meiotic chromosomes. The decreases in sperm count as well as increases in abnormality in the gross morphology of the sperm-head, as observed upon toxin treatment, was ameliorated by the vitamin A.
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