Photoelectrochemical Sensor Based on MoS2/BI2MoO6 Heterojunction for Triptriolide Detection

Thunder God Vine has multiple effects such as anti-inflammatory, anti-tumor, and anti-fertility. One of its main active ingredients, triptriolide, can exert anti-tumor effects by targeting transcription factors, kinases, or inhibiting the ubiquitin/proteasome pathway to inhibit cell proliferation and promote tumor cell apoptosis. However, its high toxicity and poor water solubility limit its application. This study aims to develop a novel photoelectrochemical (PEC) sensor based on MoS 2 /Bi 2 MoO 6 nanohybrids for the rapid and accurate detection of triptriolide. The PEC sensor is a fundamental tool for extracting and identifying valuable bioactive compounds from this plant. Under optimal conditions, 0.01–10[Formula: see text]ng[Formula: see text]mL[Formula: see text] of triptriolide could be identified, with the detection limit being as low as 0.005[Formula: see text]ng[Formula: see text]mL[Formula: see text]. With advantages like rapid response, high sensitivity and preferable stability, the developed sensor is suitable for real-time monitoring of triptriolide levels in actual samples.