脂肪生成
安普克
脂肪组织
内分泌学
脂肪细胞
内科学
胰岛素抵抗
高脂血症
肥胖
医学
药理学
糖尿病
化学
生物化学
蛋白激酶A
激酶
作者
Ling Yang,Lin-Zi Li,Qian Nan Lu,Lingfeng Li,Chun Xie,Fengling Jiang,Hongbing Li,Ai Zhao,Qian Wang,Wenyong Xiong
标识
DOI:10.1016/j.ejphar.2023.175942
摘要
As a global epidemic disease, obesity causes dysfunction of glucose and lipid metabolism leading to persistently high morbidity and mortality. Given the difficulty to achieve and maintain weight loss through controlling diet and physical exercise, pharmacotherapy is considered an effective treatment for obesity. This investigation revealed that alisol B, a triterpene monomer isolated from the classical Chinese medicine Alisma orientale (Sam.) Juzep, functioned in suppressing adipogenesis and reducing the mass of subcutaneous adipose tissue, resulting in the reduction of weight gain, and improvements of hyperglycemia, hyperlipidemia, and insulin resistance in HFD-induced obese mice. In consistent to the results, alisol B also significantly inhibited adipocyte differentiation and maturation in vitro. Furthermore, our data revealed that the effects of alisol B on adipogenesis were mediated by LKB1-AMPK signaling pathway. In total, alisol B could be a potential lead compound which contributes to the improvement of obesity-related metabolic disorders.
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