化学
差向异构体
光催化
催化作用
立体化学
布朗斯特德-洛瑞酸碱理论
对映选择合成
有机化学
组合化学
光催化
作者
Guangjin Zhen,Yi‐Nan Lu,Chun‐Jiang Wang
摘要
Herein, a novel strategy for the catalytic asymmetric synthesis of enantioenriched 3-cis- and 3-trans-substituted prolines has been successfully established via an unprecedented cascade radical addition/cyclization enabled by synergistic photoredox/Brønsted acid catalysis and subsequent base-assisted epimerization. The current protocol provides a unique de novo access to all four stereoisomers of 3-substituted prolines which are not readily achieved via currently established methods. This methodology could be further extended to the asymmetric synthesis of the full complement of stereoisomers of 3-substituted pipecolinic acids.
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