毒性
炎症性肠病
玉米赤霉烯酮
下调和上调
眼袋炎
病态的
溃疡性结肠炎
结肠炎
医学
真菌毒素
生物
免疫学
疾病
病理
内科学
生物化学
植物
基因
作者
Haonan Ruan,Jiashuo Wu,Fangqing Zhang,Ziyue Jin,Jiao Tian,Jing Xia,Jiaoyang Luo,Meihua Yang
出处
期刊:Toxins
[MDPI AG]
日期:2023-06-09
卷期号:15 (6): 392-392
被引量:1
标识
DOI:10.3390/toxins15060392
摘要
Zearalenone (ZEN), a prevalent mycotoxin contaminating food and known for its intestinal toxicity, has been suggested as a potential risk factor for inflammatory bowel disease (IBD), although the exact relationship between ZEN exposure and IBD remains unclear. In this study, we established a rat model of colon toxicity induced by ZEN exposure to investigate the key targets of ZEN-induced colon toxicity and explore the underlying connection between ZEN exposure and IBD. Histological staining of the rat colon revealed significant pathological changes resulting from ZEN exposure (p < 0.01). Furthermore, the proteomic analysis demonstrated a notable upregulation of protein expression levels, specifically STAT2 (0.12 ± 0.0186), STAT6 (0.36 ± 0.0475) and ISG15 (0.43 ± 0.0226) in the rat colon (p < 0.05). Utilizing bioinformatics analysis, we combined ZEN exposure and IBD clinical sample databases to reveal that ZEN exposure may increase the risk of IBD through activation of the STAT-ISG15 pathway. This study identified novel targets for ZEN-induced intestinal toxicity, providing the basis for further study of ZEN exposure to IBD.
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