烟酰胺磷酸核糖转移酶
烟酰胺腺嘌呤二核苷酸
烟酰胺单核苷酸
辅因子
癌症研究
化学
烟酰胺
细胞生物学
生物
NAD+激酶
生物化学
酶
作者
Massimiliano Gasparrini,Simone Giovannuzzi,Alessio Nocentini,Nadia Raffaelli,Claudiu T. Supuran
标识
DOI:10.1080/13543776.2024.2367006
摘要
Introduction Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide (NAD) from nicotinamide. In addition to its role as essential redox cofactor, NAD also functions as a substrate for NAD-consuming enzymes, regulating multiple cellular processes such as DNA repair and gene expression, fundamental to sustain energetic needs for tumor growth. In this sense, NAMPT over-expression represents a common strategy that several tumor types adopt to sustain NAD production. In addition to its enzymatic role, NAMPT behaves as cytokine-like protein with pro-inflammatory function. Increasing evidence demonstrated that NAMPT inhibition represents a promising anti-cancer strategy to deplete NAD and impair cellular metabolism in cancer conditions.
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