医学
内科学
脂肪肝
优势比
全国健康与营养检查调查
混淆
置信区间
胃肠病学
逻辑回归
疾病
人口
环境卫生
作者
Lei Pan,Lixuan Wang,Huijuan Ma,Hang Fan
摘要
Abstract Background and Aim This study aimed to investigate the relationship between advanced lung cancer inflammation index (ALI) and non‐alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis (AF). Methods A total of 5642 individuals from the National Health and Nutrition Examination Survey (NHANES) between 2017 and 2020 were examined. Limited cubic spline regression model, and weighted logistic regression were employed to determine if ALI levels were related to the prevalence of NAFLD and AF. Additionally, a mediating analysis was conducted to investigate the role of lipid biomarkers, such as total cholesterol (TC) and high‐density lipoprotein cholesterol (HDL‐C), in the effects of ALI on the prevalence of NAFLD and AF. Results After adjusting for potential confounders, a significant positive association was found between ALI with NAFLD and AF prevalence. Compared with those in ALI Tertile 1, participants in Tertile 3 had higher odds of NAFLD prevalence (odds ratio [OR]: 3.16; 95% confidence interval [CI]: 2.52–3.97) and AF (OR: 3.17; 95% CI: 2.30–4.36). Participants in both Tertile 2 and Tertile 3 had lower odds of developing AF ( P for trend = 0.005). Moreover, we discovered a nonlinear association between ALI and NAFLD. An inflection point of 74.25 for NAFLD was identified through a two‐segment linear regression model. Moreover, TC and HDL‐C levels mediated the association between ALI and NAFLD by 10.2% and 4.2%, respectively (both P < 0.001). Conclusion Our findings suggest that higher ALI levels are positively associated with an increased prevalence of NAFLD and AF, partly mediated by lipid biomarkers.
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