UCP1 and CKB are parallel players in BAT

It is generally believed that the contributions of the UCP1-independent thermogenic pathways are secondary to UCP1-mediated thermogenesis in BAT. Now, Rahbani et al. demonstrate in vivo that adaptive thermogenesis in brown adipose tissue is regulated by UCP1 and CKB in parallel. It is generally believed that the contributions of the UCP1-independent thermogenic pathways are secondary to UCP1-mediated thermogenesis in BAT. Now, Rahbani et al. demonstrate in vivo that adaptive thermogenesis in brown adipose tissue is regulated by UCP1 and CKB in parallel. Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKBRahbani et al.Cell MetabolismJanuary 24, 2024In BriefRahbani and Bunk et al. reveal that thermogenic adipocytes utilize UCP1 and CKB in parallel to support whole-body thermogenic demand in response to acute cold exposure. Full-Text PDF