免疫系统
肠道菌群
微生物群
婴儿配方奶粉
生物
免疫学
肠道菌群
婴儿营养
肠道细菌
细菌
双歧杆菌
医学
乳酸菌
生物信息学
食品科学
人口
环境卫生
遗传学
研究方法
作者
Bin Zhang,Long-Qing Li,Feitong Liu,Jian‐Yong Wu
标识
DOI:10.1016/j.carbpol.2021.118738
摘要
Human milk oligosaccharides (HMOs) are a unique class of non-digestible carbohydrates present in the mother milk, which play a key role in the development of infant gut microbiota, epithelial barrier and immune function. The deficiency of HMOs in the bovine milk-based infant formula has been widely recognized as a major culprit for the much higher incidence of immune disorders of formula-fed infants. This report was to give an up-to-date review on the structure characteristics of HMOs and the possible mechanisms, and strategies for their cellular uptake, and metabolism by the gut bacteria and the associated effects on the infant gut microbiome, and immune function. Most previous studies have been carried out in animals or in vitro model systems on the utilization strategies for HMOs in infant bacteria and their roles in infant microbiome, and gut immune function. A few HMO molecules have been synthesized artificially and applied in infant formulas.
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