Effects of neonatal alcohol and/or cocaine exposure on stress in juvenile and adult female rats

开阔地 少年 怀孕 妊娠期 胎儿酒精综合征 生理学 医学 内科学 行为绝望测验 内分泌学 心理学 麻醉 生物 海马体 生物化学 遗传学 抗抑郁药
作者
L S Hansen-Trench,Susan Barron
出处
期刊:Neurotoxicology and Teratology [Elsevier]
卷期号:27 (1): 55-63 被引量:6
标识
DOI:10.1016/j.ntt.2004.10.001
摘要

The effects of neonatal exposure to alcohol and/or cocaine on two measures of stress were studied in juvenile and young adult female rats. After implantation with an intragastric cannula, subjects were artificially reared from postnatal days 4–10. This “brain growth spurt” period is roughly equivalent to CNS development during the third trimester of human pregnancy. There were five treatment groups: alcohol (6 g/kg/day), cocaine (60 mg/kg/day), alcohol/cocaine (6 g/kg/day alcohol and 60 mg/kg/day cocaine), stock (an artificially reared control), and sham (a suckled control). Subjects were tested in open field and forced swim tests beginning at 21 or 60–70 days of age, respectively. Compared to controls, alcohol-exposed females displayed longer latencies to become immobile in the forced swim test as juveniles and cocaine-exposed females showed increased immobility as adults. Increased immobility can be interpreted as hyporesponsiveness to stress. In contrast, very few differences were observed in the open field. Furthermore, the group exposed to alcohol and cocaine in combination did not differ from controls in either paradigm. These findings suggest that the forced swim test may be more sensitive to neonatal drug effects than open field, although these effects may not be consistent across age.
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