Comments on a New Simple Route toN-Substituted 2-Aminoethylphosphonic Acids. A Reinvestigation

Abstract A recent article[1] Fu, X., Gong, C., Ma, X. and Wen, S. 1998. A new simple route to N-substituted 2-aminoethylphosphonic acids. Synth. Commun., 28(14): 2659–2664. [Taylor & Francis Online], [Web of Science ®] , [Google Scholar] reported a new route to 2-aminoethylphosphonic acid and its N-alkyl derivatives by ammonolysis and aminolysis of 2-chloroethylphosphonic acid. Attempts to reproduce these reactions failed to give aminophosphonic acids and led only to unreacted amine and phosphates with evolution of ethylene.