Creation of Pure Nanodrugs and Their Anticancer Properties

Angewandte Chemie International EditionVolume 51, Issue 41 p. 10315-10318 Communication Creation of Pure Nanodrugs and Their Anticancer Properties† Dr. Hitoshi Kasai, Corresponding Author Dr. Hitoshi Kasai hkasai@tagen.tohoku.ac.jp Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorDr. Tatsuya Murakami, Dr. Tatsuya Murakami World Premier International Research Center Initiative, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8302 (Japan)Search for more papers by this authorYoshikazu Ikuta, Yoshikazu Ikuta Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorYoshitaka Koseki, Yoshitaka Koseki Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorDr. Koichi Baba, Dr. Koichi Baba Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871 (Japan)Search for more papers by this authorProf. Hidetoshi Oikawa, Prof. Hidetoshi Oikawa Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorProf. Hachiro Nakanishi, Prof. Hachiro Nakanishi Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorDr. Masahiro Okada, Dr. Masahiro Okada Graduate School of Bioscience and Biotechnology, Chubu University, Kasugai-shi, Aichi 487-8501 (Japan)Search for more papers by this authorMitsuru Shoji, Mitsuru Shoji Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512 (Japan)Search for more papers by this authorProf. Minoru Ueda, Prof. Minoru Ueda Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578 (Japan)Search for more papers by this authorProf. Hiroshi Imahori, Prof. Hiroshi Imahori World Premier International Research Center Initiative, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8302 (Japan) Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510 (Japan)Search for more papers by this authorProf. Mitsuru Hashida, Prof. Mitsuru Hashida World Premier International Research Center Initiative, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8302 (Japan) Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan)Search for more papers by this author Dr. Hitoshi Kasai, Corresponding Author Dr. Hitoshi Kasai hkasai@tagen.tohoku.ac.jp Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorDr. Tatsuya Murakami, Dr. Tatsuya Murakami World Premier International Research Center Initiative, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8302 (Japan)Search for more papers by this authorYoshikazu Ikuta, Yoshikazu Ikuta Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorYoshitaka Koseki, Yoshitaka Koseki Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorDr. Koichi Baba, Dr. Koichi Baba Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871 (Japan)Search for more papers by this authorProf. Hidetoshi Oikawa, Prof. Hidetoshi Oikawa Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorProf. Hachiro Nakanishi, Prof. Hachiro Nakanishi Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Aoba-ku, Sendai 980-8577 (Japan)Search for more papers by this authorDr. Masahiro Okada, Dr. Masahiro Okada Graduate School of Bioscience and Biotechnology, Chubu University, Kasugai-shi, Aichi 487-8501 (Japan)Search for more papers by this authorMitsuru Shoji, Mitsuru Shoji Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512 (Japan)Search for more papers by this authorProf. Minoru Ueda, Prof. Minoru Ueda Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578 (Japan)Search for more papers by this authorProf. Hiroshi Imahori, Prof. Hiroshi Imahori World Premier International Research Center Initiative, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8302 (Japan) Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510 (Japan)Search for more papers by this authorProf. Mitsuru Hashida, Prof. Mitsuru Hashida World Premier International Research Center Initiative, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8302 (Japan) Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan)Search for more papers by this author First published: 11 September 2012 https://doi.org/10.1002/anie.201204596Citations: 113 † The Asahi Glass Foundation and the JST programs of PREST “Search for Nanomanufacturing Technology and Its Development” (Supervisor: Dr. Naoki Yokoyama) and Adaptable and Seamless Technology Transfer Program through Target-driven R&D have been greatly supportive in this study. We would also like to thank Dr. Jun Matsui and Dr. Takahiro Muraoka of IMRAM, Tohoku University, who provided fruitful discussion. In addition, we received generous support from Nao Naohara, Sayaka Ishibane, Akie Takanashi, Shoko Yamamoto, and Kenji Sugai in relation to the experimentation performed herein. We are very grateful to Prof. Shigefumi Kuwahara of Faculty of Agriculture, Tohoku University, for help with the organic synthesis and spectroscopic measurements. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201204596_sm_miscellaneous_information.pdf734.9 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume51, Issue41October 8, 2012Pages 10315-10318 RelatedInformation