Two new compounds, oresbiusin A (1) and B (2), have been isolated from Isodon oresbius. The structures of 1 and 2 were elucidated as methyl 3-(3',4'-dihydroxyphenyl) lactate and methyl 2-O-feruloyl-3-(3',4'-dihydroxyphenyl) lactate, respectively, on the basis of spectroscopic evidence.