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[Anatomico-functional approach to the mechanisms of memory: analysis by deoxyglucose of the limbic activation induced by electric stimulation of the mouse entorhinal cortex].

下托 内嗅皮质 神经科学 海马结构 海马体 穿孔通路 齿状回 前嗅核 刺激 鼻周皮质 扣带皮质 梨状皮质 扁桃形结构 边缘系统 穹窿 脾后皮质 布罗卡对角线带 化学 穿孔道 心理学 中枢神经系统 嗅球 颞叶 基底前脑 嗅结节 癫痫
作者
J. Sif,Monique Gauthier,C Destrade
出处
期刊:PubMed 卷期号:302 (11): 423-8 被引量:2
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Previous behavioral studies using post-training electrical stimulation of the brain have suggested that the lateral entorhinal cortex (LEC) is involved in mnemonic processes. In an attempt to characterize in vivo the neural pathways activated by LEC stimulation, regional patterns of uptake of 14C-2-deoxy-D-glucose (2-DG) were assessed in BALB/c mouse brain. The animals were implanted with a bipolar electrode in the LEC and a catheter in the jugular vein. In addition, four animals received an electrolytic lesion of the perforant path (PP) in order to disconnect the LEC from the hippocampus. The LEC was stimulated at subconvulsive intensity for 5 min. before and 30 min. after an injection of 2-DG. Stimulation of the LEC produced significant increases in 2-DG radioactivity in the hippocampus (dentate gyrus, CA3, CA1), subiculum and pre-subiculum. Demonstrable labelling was found in brain areas, beyond the hippocampal formation: piriform cortex, amygdala, cingulate cortex, Diagonal Band of Broca, the medial and lateral septal nuclei and the medial forebrain bundle. After PP lesion, the metabolic activity disappeared ipsilaterally in subiculum, dorsal part of the hippocampus, in some thalamic nuclei and in mammillary bodies, but all other extra-hippocampal labelling was unchanged. These data considered along with our previous behavioral results, suggest that LEC stimulation may act on mnemonic processes by the recruitment of cortical and subcortical extra-hippocampal structures (e.g. amygdala and cingulate cortex) directly or indirectly connected to the entorhinal cortex.

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