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Prediction of breast cancer molecular subtypes on DCE-MRI using convolutional neural network with transfer learning between two centers

卷积神经网络 学习迁移 深度学习 人工智能 乳腺癌 人工神经网络 计算机科学 机器学习 模式识别(心理学) 癌症 医学 内科学
作者
Yang Zhang,Jeon‐Hor Chen,Yezhi Lin,Si‐Wa Chan,Jiejie Zhou,Daniel S. Chow,Peter D. Chang,Tiffany C. Kwong,Dah‐Cherng Yeh,Xinxin Wang,Ritesh Parajuli,Rita S. Mehta,Meihao Wang,Min‐Ying Su
出处
期刊:European Radiology [Springer Science+Business Media]
卷期号:31 (4): 2559-2567 被引量:92
标识
DOI:10.1007/s00330-020-07274-x
摘要

To apply deep learning algorithms using a conventional convolutional neural network (CNN) and a recurrent CNN to differentiate three breast cancer molecular subtypes on MRI.A total of 244 patients were analyzed, 99 in training dataset scanned at 1.5 T and 83 in testing-1 and 62 in testing-2 scanned at 3 T. Patients were classified into 3 subtypes based on hormonal receptor (HR) and HER2 receptor: (HR+/HER2-), HER2+, and triple negative (TN). Only images acquired in the DCE sequence were used in the analysis. The smallest bounding box covering tumor ROI was used as the input for deep learning to develop the model in the training dataset, by using a conventional CNN and the convolutional long short-term memory (CLSTM). Then, transfer learning was applied to re-tune the model using testing-1(2) and evaluated in testing-2(1).In the training dataset, the mean accuracy evaluated using tenfold cross-validation was higher by using CLSTM (0.91) than by using CNN (0.79). When the developed model was applied to the independent testing datasets, the accuracy was 0.4-0.5. With transfer learning by re-tuning parameters in testing-1, the mean accuracy reached 0.91 by CNN and 0.83 by CLSTM, and improved accuracy in testing-2 from 0.47 to 0.78 by CNN and from 0.39 to 0.74 by CLSTM. Overall, transfer learning could improve the classification accuracy by greater than 30%.The recurrent network using CLSTM could track changes in signal intensity during DCE acquisition, and achieved a higher accuracy compared with conventional CNN during training. For datasets acquired using different settings, transfer learning can be applied to re-tune the model and improve accuracy.• Deep learning can be applied to differentiate breast cancer molecular subtypes. • The recurrent neural network using CLSTM could track the change of signal intensity in DCE images, and achieved a higher accuracy compared with conventional CNN during training. • For datasets acquired using different scanners with different imaging protocols, transfer learning provided an efficient method to re-tune the classification model and improve accuracy.
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