自愈水凝胶
明胶
肿胀 的
间充质干细胞
再生(生物学)
材料科学
坏死
体内
股骨头
生物医学工程
医学
化学
外科
病理
细胞生物学
复合材料
高分子化学
生物化学
生物
生物技术
作者
Shuai Yuan,Yaguang Han,Xiang Da Dong,Bo Wang,Yi Chen,Yangquan Hao
标识
DOI:10.1016/j.nano.2022.102521
摘要
An injectable hydroxypropyl-β-cyclodextrin (HPβCD) cross-linking of gelatin (Gel) based hydrogel was embedded with BMSC in vivo bone regeneration of femoral head necrosis. This HPβCD-Gel hydrogel possesses quick gelation within 6 min; a high-water uptake resulted in faster biodegradation, high swelling, and a 3D porous network that strengthened its mechanical, surface, and morphological properties. The results indicated that BMSC showed high cell viability (>90%) during measurement; HPβCD-Gel hydrogels induced BMSC differentiation into osteocytes within 14 days more efficiently than the osteogenic medium. The HPβCD-Gel/BMSC hydrogels that were injected into the necrosis site of the femoral head in the vessels were measured for 2 weeks. In addition, the vessel density and mean vessel diameters increased in the next 2-8 weeks followed by increased new bone formation, according to the in vivo analysis. Overall, our findings show that this method is a promising strategy for improving femoral head necrosis bone regeneration.
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