白细胞介素
白细胞介素8
白细胞介素10
白细胞介素2
受体
促炎细胞因子
白细胞介素20
作者
Minoru Hasegawa,Shinichi Sato,Hironobu Ihn,Kazuhiko Takehara
出处
期刊:Rheumatology
[Oxford University Press]
日期:1999-07-01
卷期号:38 (7): 612-617
被引量:81
标识
DOI:10.1093/rheumatology/38.7.612
摘要
Objectives. To determine whether the spontaneous production of interleukin 6 (IL-6), oncostatin M (OSM ), soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130) from peripheral blood mononuclear cells (PBMC ) is increased in patients with systemic sclerosis (SSc). Methods. The culture supernatants of PBMC from patients with SSc (n= 33) and healthy controls (n= 20) were examined by enzyme-linked immunosorbent assay. Results. The production levels of IL-6, OSM and sIL-6R were significantly higher in patients with SSc than in controls. However, sgp130 levels in supernatants from patients with SSc were not significantly elevated when compared with those from controls. Soluble IL-6R levels correlated significantly with the severity of pulmonary fibrosis in patients with SSc. Conclusions. The enhanced production of IL-6, OSM and sIL-6R from PBMC may cooperatively contribute to the disease process in SSc. In particular, enhanced sIL-6R production from PBMC may be related to the development of pulmonary fibrosis via enhancement of IL-6 signal transduction in SSc, since sIL-6R can act as an agonist of IL-6.
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