生物传感器
DNA
化学
计算生物学
量子点
酶
纳米技术
DNA复制
生物化学
生物
材料科学
作者
Qian Zhang,Xinyi Zhang,Fei Ma,Chun‐yang Zhang
标识
DOI:10.1016/j.ccr.2022.214674
摘要
DNA-modifying enzymes participate in various genetic functions (e.g., DNA replication, repairing, and recombination) through alternating certain DNA sequence, and the malfunction of DNA-modifying enzymes may disturb the normal genetic functions and consequently causes diverse human diseases. DNA-modifying enzymes may serve as the valuable diagnosis biomarkers and therapeutic targets, and the detection of DNA-modifying enzymes is essential to fundamental research, anticancer-drug discovery, and clinical diagnosis. Quantum dots (QDs) have many excellent electronic and optical characteristics, facilitating their biosensing and bioimaging applications. We review the development of QDs-based biosensors for DNA-modifying enzyme assays, and discuss current challenges and future directions in this field.
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